한국지질동맥경화학회 학술대회

This session will explore novel insights into the role of lipid toxicity and platelet signaling in the pathogenesis of atherosclerotic inflammation. Professor Ok-Nam Bae from Hanyang University, Republic of Korea, will present on how environmental toxicants such as nanoparticles and biocides disrupt lipid homeostasis and promote vascular inflammation. Professor Jun Young Hong from Yonsei University, Republic of Korea, will discuss immune-driven remodeling of lipid metabolism that induces whitening of brown adipose tissue under thermoneutral conditions, highlighting the crosstalk between immunity and energy metabolism. Professor Jin O-Uchi from University of South Florida, USA, will elucidate the functional role of the mitochondrial calcium uniporter in human platelets and its impact on platelet aggregation and thrombosis. This multidisciplinary session will offer a comprehensive view on how metabolic stress, immune dysregulation, and platelet activation converge to drive vascular pathology.

In this special session titled “Redefining Cardiovascular Care: PCSK9 Mechanisms and siRNA-Based Advances,” ICoLA 2025 brings together leading experts to explore emerging molecular and clinical insights into lipid regulation and atherosclerotic disease management. The session opens with a comprehensive exploration of PCSK9—the master regulator of LDL metabolism and a key player in vascular inflammation—highlighting its central role in atherosclerosis. The second presentation focuses on the promise of siRNA-based lipid-lowering therapies, showcasing their transformative potential for sustained LDL-C control. Finally, the session addresses novel approaches to managing familial hypercholesterolemia beyond statin therapy, offering new hope for patients with genetically driven dyslipidemia. This session integrates advances in molecular biology, therapeutic innovation, and clinical practice, paving the way for a redefined and more personalized approach to cardiovascular prevention and treatment.

Recent updates to the ASCVD risk prediction model, including the introduction of the PREVENT equation, reflect several key advances—one of which is the integration of socioeconomic factors. This shift highlights the growing recognition of social determinants as important contributors to cardiovascular risk. In this session, we will explore the multifaceted impact of socioeconomic status on ASCVD. Professor Seonghee Choi from Seoul National University Bundang Hospital, Republic of Korea, will discuss the underlying mechanisms linking socioeconomic disadvantage to cardiovascular outcomes. Professor Jongha Baek from Gyeongsang National University, Republic of Korea, will present epidemiological evidence illustrating the magnitude of this association. Finally, Professor Sadiya S. Khan from Northwestern University Feinberg School of Medicine, USA, will introduce a novel cardiovascular risk prediction model that incorporates socioeconomic variables into traditional clinical frameworks.