한국지질동맥경화학회 학술대회

As the number of elderly patients rapidly increase, this session is designed to understand the characteristics of these patients, such as their multimorbidity and fragility and to provide prevention and treatment strategies tailored to each disease and situation. Professor Dong-Ho Shin from Yonsei University, Republic of Korea, will discuss “Strategies for managing hyperlipidemia in fragile elderly patients.” Professor Soojin Yun from Kyung Hee University, Republic of Korea, will cover “Optimizing glucose control in fragile elderly patients with cardiometabolic syndrome.” Finally, Professor Hidenori Arai from National Center for Geriatrics and Gerontology, Japan, will deliver a lecture on “How to deal with multimorbidity and frailty for the prevention of cardiovascular disease.”

This session provides an in-depth exploration of the paradigm shift in obesity management from treatment to prevention. Prof. Choon Young Kim (Yeungnam University, Republic of Korea) presents the anti-obesity effects of bioactive compounds from natural products, focusing on cellular signaling and metabolic regulation. Prof. Yun Kyung Cho (University of Ulsan, Republic of Korea) discusses the therapeutic potential of semaglutide in obesity and its cardiometabolic benefits. Prof. Sang-Ho Jo (Hallym University, Republic of Korea) addresses the role of tirzepatide, a dual GIP/GLP-1 receptor agonist, in obesity treatment and comprehensive metabolic care.

This session explores the emerging clinical challenges of atherosclerosis in patients with complex comorbidities such as cancer survivorship, metabolic dysfunction, and autoimmune diseases. Professor Nuri Lee from Chonnam National University, Republic of Korea, will address the balance between cardiovascular and oncologic risks in cancer survivors, highlighting tailored lipid management strategies. Professor Won Kim from Seoul National University, Republic of Korea, will discuss metabolic dysfunction-associated steatotic liver disease (MASLD/MAFLD) as a novel cardiovascular risk equivalent. Lastly, Professor Ji-Won Kim from Daegu Catholic University, Republic of Korea, will focus on atherosclerosis in rheumatoid arthritis and systemic autoimmune diseases, providing clinical perspectives on inflammation-driven vascular risk. This session will offer invaluable insights into how systemic comorbidities alter cardiovascular risk and management, making it essential for clinicians and researchers interested in complex patient populations.

The Journal of Lipid and Atherosclerosis (JLA) Committee has selected five outstanding papers published over the past year for presentation in this session. The authors will share key findings from their research on lipid metabolism and cardiovascular risk. Professor Su Youn Nam explores the association between high-density lipoprotein cholesterol and hematologic malignancy risk, while Professor Mee Kyoung Kim discusses the role of kidney function in cholesterol-related cardiovascular risk in type 2 diabetes. Professors Hayato Tada and Wen-Liang Song present on the impact of lipoprotein(a) on coronary artery disease and fibrinolysis, respectively, and Professor Belen Davico addresses the role of fatty acids in childhood obesity and cardiovascular risk. This session offers timely insights into the evolving understanding of lipid-related mechanisms in cardiometabolic diseases.

“Dyslipidemia Management in Special Populations” explores lipid-lowering strategies tailored to unique clinical contexts. Professor Mina Kim (Korea University, Republic of Korea) will address dyslipidemia management in women before and after menopause, highlighting hormonal influences on cardiovascular risk. Professor Byung Sik Kim (Hanyang University, Republic of Korea) will discuss lipid management in patients with liver disease, focusing on the safe and effective use of statins in this vulnerable group. Finally, Professor Seonghoon Choi (Hallym University, Republic of Korea) will present on dyslipidemia in the setting of HIV infection and chronic inflammation, emphasizing pathophysiological mechanisms and therapeutic challenges. This session will provide practical insights into individualized dyslipidemia care for patients with complex comorbidities and diverse physiological backgrounds.

Lipid-immune crosstalk plays a critical role in shaping vascular repair mechanisms and the progression of atherosclerotic disease. This session highlights how specific lipid signals influence immune cell behavior and vascular pathology. Professor Younggeun Ahn from Chonnam National University, Republic of Korea, will present how IKKε-deficient macrophages impair cardiac repair post-myocardial infarction by promoting the macrophage-to-myofibroblast transition. Professor Wei Kong from Peking University, China, will discuss how ceramide sensing via CYSLTR2 and P2RY6 contributes to the aggravation of atherosclerosis, revealing novel lipid-sensing inflammatory circuits. Dr. Hyunbeom Lee from KIST, Republic of Korea, will provide a systems-level perspective on how lipidomics can be utilized to better understand human disease. This session will offer deep insights into lipid-mediated immune regulation and its implications for vascular health and therapeutic strategies.