한국지질동맥경화학회 학술대회

As the number of elderly patients rapidly increase, this session is designed to understand the characteristics of these patients, such as their multimorbidity and fragility and to provide prevention and treatment strategies tailored to each disease and situation. Professor Dong-Ho Shin from Yonsei University, Republic of Korea, will discuss “Strategies for managing hyperlipidemia in fragile elderly patients.” Professor Soojin Yun from Kyung Hee University, Republic of Korea, will cover “Optimizing glucose control in fragile elderly patients with cardiometabolic syndrome.” Finally, Professor Hidenori Arai from National Center for Geriatrics and Gerontology, Japan, will deliver a lecture on “How to deal with multimorbidity and frailty for the prevention of cardiovascular disease.”

Professor Kausik Kumar Ray is a Professor of Public Health and Primary Care at Imperial College London and Honorary Consultant Cardiologist at Imperial College NHS Trust. He is the Immediate Past President of the European Atherosclerosis Society and the Chair of the World Heart Federation Cholesterol Roadmap Committee. As a globally recognized expert in clinical trials and epidemiological research, his work has been cited over 178,000 times worldwide. In this plenary lecture titled “Cholesterol lowering throughout the life-course to prevent atherosclerotic cardiovascular disease-a pragmatic population health approach,” Professor Ray will highlight the importance of lipid management across the entire life course. The session will explore evidence-based strategies for the prevention of atherosclerotic cardiovascular disease (ASCVD), emphasizing a pragmatic and population-wide approach to cholesterol reduction.

In Keynote Lecture 2, Professor Jacob Fog Bentzon from Aarhus University, Denmark, will present his latest findings on “The role of smooth muscle cells in atherosclerotic plaque progression.” As a global authority in experimental atherosclerosis research, Professor Bentzon leads a team focused on uncovering the cellular mechanisms of atherosclerosis and identifying novel therapeutic targets. This lecture will explore the heterogeneity and phenotypic modulation of smooth muscle cells within atherosclerotic plaques and their impact on plaque stability and cardiovascular events. Bridging fundamental science and clinical relevance, this keynote will provide critical insights for those seeking to understand the pathobiology of atherosclerosis and to develop future treatment strategies.

Professor Hong June Yoo, Endowed Director General, National Museum of Korea, Republic of Korea, is a leading scholar who has played a pivotal role in bringing Korean art history and garden culture to the public. In this special lecture, Professor Yoo will explore the aesthetic differences between Eastern and Western approaches to gardens, and introduce the uniquely nature-oriented philosophy embodied in traditional Korean gardens. This lecture offers a unique opportunity to reflect on how Korean gardens express a deep respect for nature and reveal a way of life that seeks harmony with the natural world.

The KoSFoST–KSoLA Joint Symposium on the “Role of Medicinal Foods in Atherosclerosis and Cardiometabolic Disease” was co-organized by the Health Functional Foods Division of the Korean Society of Food Science and Technology (KoSFoST) and the Korean Society of Lipid and Atherosclerosis (KSoLA). Professor Hun-Jun Park (Catholic University of Korea, Republic of Korea) will discuss novel health functional products designed to prevent pathological remodeling after myocardial infarction. Professor Sung Keun Jung (Kyungpook National University, Republic of Korea) will highlight how ultrasonicated Lespedeza cuneata extract can prevent early atherosclerosis, underscoring the critical role of processing techniques. Finally, Dr. Jiyun Ahn (Korea Food Research Institute, Republic of Korea) will examine strategies for regulating mitochondrial metabolic reprogramming during aging and provide systematic insights for anti-aging interventions. Following these distinguished presentations, the session will proceed with in-depth discussions regarding the role and practical development of medicinal foods in managing atherosclerosis and cardiometabolic disease.

This session explores the emerging clinical challenges of atherosclerosis in patients with complex comorbidities such as cancer survivorship, metabolic dysfunction, and autoimmune diseases. Professor Nuri Lee from Chonnam National University, Republic of Korea, will address the balance between cardiovascular and oncologic risks in cancer survivors, highlighting tailored lipid management strategies. Professor Won Kim from Seoul National University, Republic of Korea, will discuss metabolic dysfunction-associated steatotic liver disease (MASLD/MAFLD) as a novel cardiovascular risk equivalent. Lastly, Professor Ji-Won Kim from Daegu Catholic University, Republic of Korea, will focus on atherosclerosis in rheumatoid arthritis and systemic autoimmune diseases, providing clinical perspectives on inflammation-driven vascular risk. This session will offer invaluable insights into how systemic comorbidities alter cardiovascular risk and management, making it essential for clinicians and researchers interested in complex patient populations.

The Journal of Lipid and Atherosclerosis (JLA) Committee has selected five outstanding papers published over the past year for presentation in this session. The authors will share key findings from their research on lipid metabolism and cardiovascular risk. Professor Su Youn Nam explores the association between high-density lipoprotein cholesterol and hematologic malignancy risk, while Professor Mee Kyoung Kim discusses the role of kidney function in cholesterol-related cardiovascular risk in type 2 diabetes. Professors Hayato Tada and Wen-Liang Song present on the impact of lipoprotein(a) on coronary artery disease and fibrinolysis, respectively, and Professor Belen Davico addresses the role of fatty acids in childhood obesity and cardiovascular risk. This session offers timely insights into the evolving understanding of lipid-related mechanisms in cardiometabolic diseases.

“Dyslipidemia Management in Special Populations” explores lipid-lowering strategies tailored to unique clinical contexts. Professor Mina Kim (Korea University, Republic of Korea) will address dyslipidemia management in women before and after menopause, highlighting hormonal influences on cardiovascular risk. Professor Byung Sik Kim (Hanyang University, Republic of Korea) will discuss lipid management in patients with liver disease, focusing on the safe and effective use of statins in this vulnerable group. Finally, Professor Seonghoon Choi (Hallym University, Republic of Korea) will present on dyslipidemia in the setting of HIV infection and chronic inflammation, emphasizing pathophysiological mechanisms and therapeutic challenges. This session will provide practical insights into individualized dyslipidemia care for patients with complex comorbidities and diverse physiological backgrounds.

The importance of remnant cholesterol has been increasingly highlighted in atherosclerotic cardiovascular diseases and various other diseases. First, Prof. Alberto Zambon from the University of Padua, Italy, will present on the mechanisms by which remnant cholesterol contributes to atherosclerotic cardiovascular disease and its clinical significance. Next, Prof. Soo Yeon Jang from Korea University, Republic of Korea, will present the role of remnant cholesterol in chronic kidney disease, and Prof. Han Na Jung from Hallym University, Republic of Korea, will present on its role in dementia. Lastly, Prof. Meral Kayikcioglu from Ege University, Türkiye, will present the role of remnant cholesterol in women's cardiometabolic health. We hope this session will reaffirm the importance of remnant cholesterol and serve as an opportunity to broaden our knowledge.

Lipid-immune crosstalk plays a critical role in shaping vascular repair mechanisms and the progression of atherosclerotic disease. This session highlights how specific lipid signals influence immune cell behavior and vascular pathology. Professor Younggeun Ahn from Chonnam National University, Republic of Korea, will present how IKKε-deficient macrophages impair cardiac repair post-myocardial infarction by promoting the macrophage-to-myofibroblast transition. Professor Wei Kong from Peking University, China, will discuss how ceramide sensing via CYSLTR2 and P2RY6 contributes to the aggravation of atherosclerosis, revealing novel lipid-sensing inflammatory circuits. Dr. Hyunbeom Lee from KIST, Republic of Korea, will provide a systems-level perspective on how lipidomics can be utilized to better understand human disease. This session will offer deep insights into lipid-mediated immune regulation and its implications for vascular health and therapeutic strategies.

This symposium, titled “Recent Evidence in Non-Invasive Cardiovascular Risk Assessment Techniques,” will explore state-of-the-art methods for cardiovascular risk stratification without the need for invasive procedures. Professor Nor Ashikin Binti Md Sari (Universiti Malaya, Malaysia) will present the latest updates on coronary artery calcium (CAC) scoring and its clinical relevance. Professor Jun Hwa Hong (Eulji University, Republic of Korea) will delve into the role of carotid ultrasonography in the primary prevention of cardiovascular disease, highlighting its utility in early detection. Lastly, Professor Hack-Lyoung Kim (Seoul National University, Republic of Korea) will discuss the clinical usefulness of brachial-ankle pulse wave velocity (baPWV) for cardiovascular risk prediction in Asian populations.